What Ibutamoren (MK-677) is
Orally active ghrelin-receptor agonist investigated for raising GH/IGF-1, appetite, sleep and body composition. It is also referred to as MK-677 and Ibutamoren mesylate.
How it works
Non-peptide GHS-R1a agonist that increases endogenous GH and IGF-1 secretion.
What the evidence shows
Multiple human studies demonstrate endocrine effects; it remains unapproved in the U.S.
Evidence level: B — Human randomized-trial evidence.
Routes studied: Oral.
Doses studied: Published clinical-study doses vary, and there is no approved protocol. This is not a True Heal Wellness recommendation.
What this page does not claim
Ibutamoren is a non-peptide investigational compound, not an approved medicine.
Safety considerations
Can increase appetite, edema, fasting glucose and insulin resistance.
- Cautions and contraindications: Diabetes/glucose intolerance, active malignancy or GH-sensitive conditions require review.
- Possible interactions: Glucose-lowering drugs, other GH-axis agents.
Sport and anti-doping
Prohibited as a GH secretagogue in sport.
Availability at True Heal Wellness
True Heal Wellness does not offer, sell or administer Ibutamoren (MK-677). This page exists as an educational reference only.