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Cognitive & NootropicResearch Only · Not FDA-Approved

PE-22-28Spadin analog targeting TREK-1

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Research Only · Not FDA-Approved. Not FDA-approved. Provided as an educational reference only — not offered or sold by True Heal Wellness. True Heal Wellness does not offer, sell, or administer PE-22-28; this page is provided strictly as an educational reference.
Mechanism
Designed to inhibit TREK-1 potassium-channel signaling.
Researched For
TREK-1 research · Mood models · Neuroplasticity
The essentials

At a Glance

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Compound type

Experimental peptide

Researched for

TREK-1 research, mood models and neuroplasticity.

Evidence level

E — Experimental

U.S. FDA status

Not FDA-approved.

Routes studied

Experimental.

Doses studied

No established human therapeutic dose.

Safety notes

Human safety is not established.

Anti-doping (WADA)

Unknown.

Availability at True Heal

True Heal Wellness does not offer, sell or administer PE-22-28. This page exists as an educational reference only.

Last reviewed

2026-08-11

Regulatory status

Not FDA-approved.

PE-22-28 is not an antidepressant treatment.

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What PE-22-28 is

Experimental spadin-derived peptide investigated for TREK-1 potassium-channel modulation and antidepressant/neuroplasticity biology. It is also referred to as Spadin analog.

How it works

Designed to inhibit TREK-1 potassium-channel signaling.

What the evidence shows

Evidence is predominantly preclinical.

Evidence level: E — Experimental.

Routes studied: Experimental.

Doses studied: No established human therapeutic dose.

What this page does not claim

PE-22-28 is not an antidepressant treatment.

Safety considerations

Human safety is not established.

  • Possible interactions: CNS-active medicines.

Sport and anti-doping

Unknown.

Availability at True Heal Wellness

True Heal Wellness does not offer, sell or administer PE-22-28. This page exists as an educational reference only.

Straight answers

Frequently asked

What is PE-22-28?

Experimental spadin-derived peptide investigated for TREK-1 potassium-channel modulation and antidepressant/neuroplasticity biology.

Is PE-22-28 FDA-approved?

Not FDA-approved. PE-22-28 is not an antidepressant treatment.

What is PE-22-28 researched for?

TREK-1 research, mood models and neuroplasticity.

What does the evidence on PE-22-28 show?

Evidence is predominantly preclinical. Evidence level: E — Experimental.

What are the safety considerations with PE-22-28?

Human safety is not established.

Does True Heal Wellness offer PE-22-28?

True Heal Wellness does not offer, sell or administer PE-22-28. This page exists as an educational reference only.

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The evidence

References

  1. PepEd Hub — PE-22-28 compound profile. pepedhub.com
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Medical disclaimer. For research and educational purposes only. This content does not constitute medical advice — consult a qualified healthcare provider before beginning any protocol.

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