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MetabolicResearch Only · Not FDA-Approved

TesofensineOral triple monoamine reuptake inhibitor

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Research Only · Not FDA-Approved. Not FDA-approved. Provided as an educational reference only — not offered or sold by True Heal Wellness. True Heal Wellness does not offer, sell, or administer Tesofensine; this page is provided strictly as an educational reference.
Mechanism
Inhibits norepinephrine, serotonin and dopamine reuptake, altering central appetite and reward signaling.
Researched For
Obesity · Appetite regulation · Energy expenditure
The essentials

At a Glance

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Compound type

Small molecule

Researched for

Obesity, appetite regulation and energy expenditure.

Evidence level

B — Human phase 2/3 evidence

U.S. FDA status

Not FDA-approved in the U.S.; investigational/market status varies by country.

Routes studied

Oral.

Doses studied

Published phase 2 research evaluated 0.25, 0.5 and 1.0 mg daily. Research doses only — not U.S. prescribing recommendations.

Safety notes

Dry mouth, nausea, constipation, insomnia and increased heart rate have been reported.

Anti-doping (WADA)

Likely prohibited if stimulant-like/performance context; verify.

Availability at True Heal

True Heal Wellness does not offer, sell or administer Tesofensine. This page exists as an educational reference only.

Last reviewed

2026-08-11

Regulatory status

Not FDA-approved in the U.S.; investigational/market status varies by country.

Tesofensine is a non-peptide small molecule and is not a GLP-1 drug.

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What Tesofensine is

Oral monoamine reuptake inhibitor investigated for obesity; it is not a peptide. It is also referred to as NS2330.

How it works

Inhibits norepinephrine, serotonin and dopamine reuptake, altering central appetite and reward signaling.

What the evidence shows

Human obesity trials have shown weight loss, but it is not FDA-approved in the U.S.

Evidence level: B — Human phase 2/3 evidence.

Routes studied: Oral.

Doses studied: Published phase 2 research evaluated 0.25, 0.5 and 1.0 mg daily. Research doses only — not U.S. prescribing recommendations.

What this page does not claim

Tesofensine is a non-peptide small molecule and is not a GLP-1 drug.

Safety considerations

Dry mouth, nausea, constipation, insomnia and increased heart rate have been reported.

  • Cautions and contraindications: Cardiovascular and psychiatric history requires clinician review.
  • Possible interactions: MAOIs, serotonergic/adrenergic drugs and CYP interactions require pharmacist review.

Sport and anti-doping

Likely prohibited if stimulant-like/performance context; verify.

Availability at True Heal Wellness

True Heal Wellness does not offer, sell or administer Tesofensine. This page exists as an educational reference only.

Straight answers

Frequently asked

What is Tesofensine?

Oral monoamine reuptake inhibitor investigated for obesity; it is not a peptide.

Is Tesofensine FDA-approved?

Not FDA-approved in the U.S.; investigational/market status varies by country. Tesofensine is a non-peptide small molecule and is not a GLP-1 drug.

What is Tesofensine researched for?

Obesity, appetite regulation and energy expenditure.

What does the evidence on Tesofensine show?

Human obesity trials have shown weight loss, but it is not FDA-approved in the U.S. Evidence level: B — Human phase 2/3 evidence.

What are the safety considerations with Tesofensine?

Dry mouth, nausea, constipation, insomnia and increased heart rate have been reported. Cautions: Cardiovascular and psychiatric history requires clinician review.

Does True Heal Wellness offer Tesofensine?

True Heal Wellness does not offer, sell or administer Tesofensine. This page exists as an educational reference only.

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The evidence

References

  1. PepEd Hub — Tesofensine compound profile. pepedhub.com
  2. Developer / additional source. pubmed.ncbi.nlm.nih.gov
Your next step

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Medical disclaimer. For research and educational purposes only. This content does not constitute medical advice — consult a qualified healthcare provider before beginning any protocol.

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